Inhalation Studies: Foundations and Techniques

This significantly updated and expanded new edition presents the scientific foundations of inhalation research essential to the design and conduct of toxicologic studies. It incorporates the major advances that have been made in the field, including recent advances in biology and the rapidly increasing global concerns and studies on particulate air pollution.The Second Edition was motivated by:new developments in the ultrafine particle health effects and concentrated aerosol researchadvances in understanding postnatal lung growth and the deposition and clearance of inhaled particlesnew techniques in toxicity testingthe explosion of knowledge in the genetic and molecular realmsthe introduction of a large number of transgenic animal modelsupdated ethical guidelines for animal testingthe emergence of aerosol medicinethe growing threat of aerosol-related terrorismincreased appreciation of nonpulmonary effects of inhaled substancesuse of medical scanning techniques to study respiratory tract structurethe introduction of new inhalation exposure systemsthe emergence of aerosol concentrators for use in air pollution studies